Aggregated NETs Sequester and Detoxify Extracellular Histones
نویسندگان
چکیده
منابع مشابه
Extracellular histones inhibit efferocytosis.
The uptake and clearance of apoptotic cells by macrophages and other phagocytic cells, a process called efferocytosis, is a major component in the resolution of inflammation. Increased concentrations of extracellular histones are found during acute inflammatory states and appear to contribute to organ system dysfunction and mortality. In these studies, we examined the potential role of histones...
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Pentraxin 3 (PTX3) is a soluble pattern recognition molecule that plays critical roles in innate immunity. Its fundamental functions include recognition of microbes, activation of complement cascades, and opsonization. The findings that PTX3 is one of the component proteins in neutrophil extracellular traps (NETs) and binds with other NET proteins imply the importance of PTX3 in the NET-mediate...
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Recent work suggests that extracellular (cell-free) nucleic acids, both DNA and RNA species, as well as extracellular nucleosomes can activate blood coagulation and promote thrombosis in vitro and in vivo (1, 2). Indeed, they substantially contribute to the development of microvascular thrombosis which can act as an intravascular immune response to circulating bacteria and has been termed immun...
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Over the last twenty years, the debilitating clinical condition known as sepsis has tripled in frequency to become the tenth leading cause of death in the United States. Extracellular histones were previously reported to mediate cell damage and organ dysfunction during hyperinflammatory response, a characteristic feature of sepsis. Lipopolysaccharide (LPS) is an endotoxin found in Gramnegative ...
متن کاملLung inflammation and damage induced by extracellular histones.
Despite decades of research, acute respiratory distress syndrome (ARDS) remains an important clinical challenge due to an incomplete understanding of the pathophysiological mechanisms. No FDA-approved drug therapy currently exists for treatment of humans with ARDS. There is accumulating evidence in rodents and humans suggesting that extracellular histones are strong drivers of inflammation and ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.02176